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Sinclair was born in Baltimore, Maryland, to Upton Beall Sinclair Sr. and Priscilla Harden Sinclair.
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As he was growing up, Upton's family moved frequently, as his father was not successful in his career. He developed a love for reading when he was five years old. He read every book his mother owned for a deeper understanding of the world. He did not start school until he was 10 years old.
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Upton Sinclair considered himself a poet and dedicated his time to writing poetry. In 1904, Sinclair spent seven weeks in disguise, working undercover in Chicago's meatpacking plants to research his novel, The Jungle
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The Jungle, a political exposé that addressed conditions in the plants, as well as the lives of poor immigrants. When it was published two years later, it became a bestseller. Sinclair had spent about six months investigating the Chicago meatpacking industry for Appeal to Reason, the work which inspired his novel. He intended to "set forth the breaking of human hearts by a system which exploits the labor of men and women for profit"
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Sinclair wrote in Cosmopolitan in October 1906 about The Jungle: "I aimed at the public's heart, and by accident I hit it in the stomach."The novel brought public lobbying for Congressional legislation and government regulation of the industry, including passage of the Meat Inspection Act and the Pure Food and Drug Act.
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After reading The Jungle, Roosevelt agreed with some of Sinclair's conclusions. He said, "Radical action must be taken to do away with the efforts of arrogant and selfish greed on the part of the capitalist."
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In the 20th century and led to the creation of the Food and Drug Administration. Its main purpose was to ban foreign and interstate traffic in adulterated or mislabeled food and drug products,
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The Federal Meat Inspection Act of 1906 (FMIA) is an American law that makes it illegal to adulterate or misbrand meat and meat products being sold as food, and ensures that meat and meat products are slaughtered and processed under strictly regulated sanitary conditions
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In 1913–1914, Sinclair made three trips to the coal fields of Colorado, which led him to write King Coal and caused him to begin work on the larger, more historical The Coal War. In 1914, Sinclair helped organize demonstrations in New York City against Rockefeller at the Standard Oil offices. The demonstrations touched off more actions by the Industrial Workers of the World (IWW).
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The Sinclair's moved to California in the 1920s and lived there for nearly four decades. During his years with his second wife, Mary Craig, Sinclair wrote or produced several films.
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He moved to Buckeye, Arizona before returning east to Bound Brook, New Jersey, where Sinclair died in a nursing home on November 25, 1968, a year after his wife.