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The Cluniac Order is founded in Cluny with the aim of reforming the church, encouraging more spirituality and combatting corruption. It's a success.
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The Holy Roman Emperor John VIII removes Pope John VIII on charges of sacrilege, simony, perjury, murder, adultery and incest.
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The Ottonian and Salian kings had entered a campaign of reform to remove the Papacy from the control of the Roman Nobility. Gerbert was Otto III's teacher and would go on to take the name Sylvester II.
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Henry, king of the Salian Germans appointed by his nobility, would initiate the Investiture Conflict.
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Pope Gregory VII, or Hildebrand, was an Italian. One of many reforming Popes, he's most famous for his campaign against lay investiture; sadly, his conflict over this with Henry IV would lead to his deposition and death.
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Hildebrand, an Italian reforming monk, becomes Pope Gregory VII. He believes the Papacy to be superior to kingship. He not only bans lay investiture but threatens to excommunicate all who follow it.
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The Concordat of Worms settles the Investiture debate: the Church would appoint clergy and nobles/kings could give them land to gain fealty.