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Matthew was born on March 9, 1980, in Las Vegas, Nevada. His father, John Gubler, is an attorney, and his mother, Marilyn Kelch Gubler, is a rancher, political consultant, and former chair of the Nevada Republican Party
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Matthew attended the Las Vegas Academy of International Studies, Performing and Visual Arts and majored in drama. He however did not have the intention of making a career out of it- he did it merely for the fun of it. He graduated in 1998.
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Matthew enrolled at the University of California at Santa Cruz but he soon transferred to New York University's Tisch School of the Arts to study film making and directing. He graduated in 2002.
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Not too long after Matthew graduated he was approached by a modeling agent as he was walking down a street and was asked if he wanted to pursue a modeling career. Over the next two years Matthew became one of the most sought out male models in New York City.
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Matthew never gave up on making films and took an internship with screenwriter and director Anderson. As a reward for his hard work, Anderson cast Gubler as Intern #1 in his 2004 film The Life Aquatic With Steve Zissou, starring Bill Murray and Owen Wilson.
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Almost immediately after, Gubler landed the role of Dr. Spencer Reid (a genius FBI agent who holds three Ph.D. degrees despite being only in his mid-20s) on the Criminal Minds. Everyone thought the show would not last past the first season but ended up having 15 seasons, ending in 2020.
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Matthew also voiced Simon in the Alvin and the Chipmunks 1-4.
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Gubler wrote and illustrated the New York Times bestseller Rumple Buttercup: A Story of Bananas, Belonging and Being Yourself, released on April 2, 2019.
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Matthew started making some "mocumentaries" on YouTube. He sometimes focuses more them then the actual show.
