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Initial contact of an allergen is made.
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Large amounts of an allergen specific IgE Antibodies are made.
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The IgE molecules set out to find histamine-producting mast cells
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The IgE molecules attach to mast cells ('priming' them).
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Upon re-exposure to an allergen, the IgE primed mast cells releases large amounts of histamine and other inflammatory chemicals
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The chemicals released cause an allergic reaction.
