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Contrary to many of his time, Aristotle believed matter was not made of atoms.
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Early Greek philosphers, such as Democritus and Leucippus, contrary to many beleifs, believed matter is made of atoms.
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The Alchemists were people who claimed that their scientific practices were the precursors to profound powers. One of their actions was trying to turn base metals into gold.
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Antoine Lavoisier stated that that matter can be changed from one form into another, mixtures can be separated or made, and pure substances can be decomposed, but the total amount of mass stays constant.
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John Dalton proposed an atomic theory with spherical solid atoms based upon measurable properties of mass.
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Joseph Proust stated that a chemical compound always contains exactly the same proportion of elements by mass.
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Henri Becquerel, when studying the properties of x-rays, proved that uranium emitted radiation without an external source of energy. This was the discovery of radioactivity.
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J.J. Thompson placed cathode tubes in electric and magnetic fields. The cathode rays bent, so he knew there were particles, electrons.
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As an explanation for electrons losing energy, Max Planck said that energy, at the sub-atomic level, can only be transfered in small units, quanta or photons.
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Marie and Pierre Curie noticed radioactivity in unique minerals with radium and uranium.
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Albert Einstein discovered the origin of energy from nuclear experiments, otherwise known as E=mc^2, the relativity equation. This means that energy is equal to mass multiplied by the speed of light squared.
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While Ernest Rutherford was a professor at Manchester, he announced each atom has a nucleus. This ultimately led to the splitting of the aton, 20 years later
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Robert Millikan, performing his oil drop experiement, was able to discover the charge of an electron.
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Henry Moseley used equipment he built himself to discover that each element has its own atomic number.
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Niels Bohr proposed a model for the hydrogen atom, showing that electrons orbit around the nucleus at different distances
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James Chadwick used scattering data to calculate the mass of this neutral particle, discovering the neutron.
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Lise Meitner, Otto Hahn, and Fritz Straussman all contributed to the discovery of nuclear fission, during the second World War.
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Martin Karplus, Michael Levitt, and Arieh Warshel by developing these models, made it possible to simulate the dynamics of complext chemical systems.