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In the 1940s,Alfred Gilman and Louis S. Goodman, started to research the chemical Nitrogen Mustard that is used in chemical warfare, as they thought it would have medical benifits.
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In 1955 the United States Congress made the National Cancer Chemotherapy Service Center (NCCSC) because of the sucess of the anti- cancer drugs
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In 1958, Roy Hertz and Min Chiu Li from the National Cancer Institute discovered that methotrexate could cure choriocarcinoma, making it the first tumor curable.
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In 1965, James Holland, Emil Freireich, and Emil Frei discovered a breakthrough in chemotherapy. They determined that using several different drugs in a cycle would make the stopping of the tumor more effective. This was called the POMP regiment, and is used a lot today in chemotherapy.