The Corps of Discovery leave St. Louis. There were fourty-three men.
"The best authenticated accounts informed us, that we were to pass through a country possessed by numerous, powerful and warlike nations of savages, of gigantic stature, fierce, treacherous and cruel; and particularly hostile to white men. And fame had united with tradition in opposing mountains to our course, which human enterprize and exertion would attempt in vain to pass." Patrick Gass
(Their spelling not mine)