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He began engaging in government-supported privateering when he was young, in 1481, following his uncle Kemal Reis,
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he took part in many naval wars of the Ottoman Empire against Spain, the Republic of Genoa and the Republic of Venice, including the First Battle of Lepanto (Battle of Zonchio).
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When his uncle Kemal Reis died in 1511, Piri returned to Gelibolu, where he started working on his studies about navigation.
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He participated in the Siege of Rhodes against the Knights of St. John, which ended with the island's surrender to the Ottomans on 25 December 1522
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The second book (1525) has a total of 210 portolan charts. he second section starts with the description of the Dardanelles Strait and continues with the islands and coastlines of the Aegean Sea, Ionian Sea, Adriatic Sea, Tyrrhenian Sea, Ligurian Sea, the French Riviera, the Balearic Islands, the coasts of Spain, the Strait of Gibraltar, the Canary Islands, the coasts of North Africa, Egypt and the River Nile, the Levant and the coastline of Anatolia.
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When he refused to support the Ottoman Vali (Governor) of Basra, Kubad Pasha, in another campaign against the Portuguese in the northern Persian Gulf, Piri Reis was publicly beheaded in 1554 or 1555.