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in 1543 he married Princess Maria of Portugal whom was his cousin she gave birth to his son but died four days after from internal hemorrhaging.
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seeking peace with England king Philip married another one of his cousins Queen Mary I of England (bloody Mary).
side note (after Mary died Philip tried to marry her younger sister) -
Philip married a french princess known as Princess Elisabeth of Valois whom was initially intended to marry his son but Philip married her instead. Elisabeth gave Philip two daughters but died due to complications of the second daughters birth.
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king Philips first son and heir to the throne died from starving himself in protest after his father imprisoned him in his room because of his plans to leave Spain.
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his fourth marriage was to his nice his niece Anna. who gave him a son, Philip the 3rd.in 1578. their marriage ended after Anna's death on October 3rd 1580
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in the year 1580 the reining king of Portugal dies and king Philip seizes control over Portugal which vastly expanded his empire
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while the nether-lands were revolting against Philip the II put a reward on the leader of the resistance against him and he was soon assassinated in 1584 by a catholic fanatic.