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Samuel Langhorne Clemens, aka Mark Twain, was born in Florida, Missouri.
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Twain's father, John Marshall Clemens, died from pneumonia. After his death, the family fell into financial hardship.
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The short story "Jim Smiley and His Jumping Frog" gets published, which rises Twain's profile as a writer.
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Mark Twain got married to Olivia "Livy" Langdon.
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Twain's wife died in Florence, Italy from congestive heart failure.
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Mark Twain died in Redding, Connecticut from a heart attack.