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The witches predict he will become thane of condor and then become king.
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As they rejoin the real world they discover that the thane has been executed. They also discover that Macbeth has been given the title because of his bravery and loyalty on the battlefeild.
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After the first prediction came true Macbeth and his wife did whatever they could to make sure the second came true as well: that Macbeth would get the crown.
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He killed all his friends, fellow wariors, and the king all to try and get the crown.
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The king's servants were first drugged by Lady Macbeth as Macbeth kills the king. To make sure they weren't caught, Lady Macbeth smears the kings blood on the servants to frame them.
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Banquo's ghost haunts Macbeth who is the only one that can see it. This drives Macbeth insane and Lady Macbeth has to make up excuses to his insanity.
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They gave him three more prediction: Beware of Macduff, marching forest, and that he cannot be killed.
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Macbeth tries to kill Macduff but he was not home at the time so he killed Macduff's wife and kids instead.
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A doctor watches Lady Macbeth who is sleepwalking because of her insanity. She dies soon after.
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Soon after the death of his wife he finds out that there is a forest coming his way. He goes to the battle feild to protect the prophecy. Fighting Macduff who was upset about his wife and children being murdered, he thought he couldn't die. He was wrong. Macduff who had been "ripped" from his mother's womb killed him.