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Lorenzo de’Medici born, in Florence, to Piero di Cosimo de’Medici and Lucrezia Tornabouni.
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His grandfather Cosimo dies; his father, Piero, assumes charge of the affairs of Florence.
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Visits Ferdinand of Aragon in Naples; begins active participation in public affairs in Florence.
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He marries Clarice Orsini
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His father dies, and two days later he accepts the charge of head of the Florentine state.
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Birth of his first male child, Piero II
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Beginning of hostilities between Lorenzo and Pope Sixtus IV; establishment of the alliance between Milan, Venice, and Florence.
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The Conspiracy of the Pazzi results in the death of Lorenzo’s brother Giuliano, and in the consolidation of Lorenzo’s own power in Florence. The Pope places the city under an interdiction and enlists the aid of the king of Naples against Florence.
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Lorenzo’s bold visit to King Ferdinand in Naples achieves an accord; at the end of the year, the Pope lifts the interdiction against Florence.
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His mother Lucrezia dies.
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Lorenzo dies at Careggi