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Marriage of Isabel of Castilla and Fernando of Aragón
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Isabel becomes Queen Isabel I of Castilla
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Fernando becomes king Fernando II of Aragón
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Conquest of Granada.Discovery of America
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Isabel I of Castilla dies. Her daugnter Juana is still young so Fernando II Aragón becomes regent of Castilla
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Juana of Castilla, Juana the Mad, suffers from mental illness.His father rules as regent until his death
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After Fernando's death, Cardinal Cisneros becomes regent before Juana's son Carlos V became king of Spain