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Maria of Portugal dies while giving birth to their ill-fated Don Carlos.
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Mary I of England dies at the St. James Palace due to an influenza epidemic at age 42.
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King Philip II built the palace of El Escorial in Madrid on the slopes of the Sierra de Guadarrama.
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Elizabeth of Valois had a miscarriage and died the same day as well as her newborn infant daughter.
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Anna of Austria died due to heart failure 8 months after giving birth to her last child.