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Koop attended Dartmouth College and Cornell Medical College for his BS and MD degrees, respectively. He then trained at the Pennzylvania Hospital in Phiadelphia, University of Pennsylvania School of Medicine, and Children's Hospital in Boston.
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He gave up his position shortly before his term expired so he could become chairman of the National Safe Kids Campaign, his last initiative as surgeon general.
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Dartmouth College, Koop's alma mater, created the C. Everett Koop Institute and had him as a Senior Scholar.
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