Alexander The Great By Reynar27 356 BCE Alexander the great was born 338 BCE Was left in charge of Macedonia 336 BCE Took over Macedonian Throne 333 BCE Battle of Issus 332 BCE Battle of Tyre 332 BCE Established Alexandria 331 BCE Become Persian King 328 BCE General Cleithus was killed 326 BCE Indian Campaign 325 BCE Reached city of Susa in Persia 323 BCE Alexander the Great Died