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1687, Publication of the Philosophiæ Naturalis Principia Mathematica, England, Sir Isaac Newton.
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1813,First exposition of the rocket equation based on Newton's third law of motion: Treatise on the Motion of Rockets, United Kingdom UK,William Moore
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1903, Inspired by the writings of Jules Verne, first serious work published that showed physical space exploration was theoretically possible: The Exploration of Cosmic Space by Means of Reaction Devices, Russia Konstantin Tsiolkovsky
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1924 Society for Studies of Interplanetary Travel founded in Soviet Union, Soviet Union members include Konstantin Tsiolkovsky, Friedrich Zander, Yuri Kondratyuk
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16 March 1926 Goddard launches the first liquid-fueled rocket United States Robert H. Goddard
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1927 Verein für Raumschiffahrt (Society for Space Travel) formed; it includes many top European rocket scientists. Flag of Germany (3-2 aspect ratio).svg Germany
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1931 First German military liquid-fueled rocket engines developed Germany Walter Riedel
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1933 Work begins on the Aggregate series of rockets which leads to the V-2 rocket. Germany Wernher von Braun
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3 October 1942 First vehicle to cross the Kármán line (100 km/~62 mi above the Earth's surface) and thereby enter outer space Germany V-2 rocket, military program
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10 May 1946 First space research flight (cosmic radiation experiments) United States captured and improved V-2 rocket
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22 May 1946 First U.S.-designed rocket to reach edge of space (80 km (49 mi)) United States WAC Corporal
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24 October 1946 First pictures of earth from 105 km (65 mi) United States V-2
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20 February 1947 First animals in space (fruit flies) [1][2] Flag of the United States.svg United States V-2
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4 October 1957 First artificial satellite
First signals from space USSR Sputnik 1 -
3 November 1957 First animal in orbit, the dog Laika Flag of the Soviet Union.svg USSR Sputnik 2
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January 1959 First firing of a rocket in Earth orbit
First reaching Earth escape velocity or Trans Lunar Injection
First detection of solar wind USSR Luna 1 -
4 January 1959 First artificial satellite to reach the Moon vicinity and first artificial satellite in heliocentric orbit USSR Luna 1
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12 April 1961 First human spaceflight–(Yuri Gagarin)
First human-crewed orbital flight USSR Vostok 1 -
14 December 1962 First planetary flyby by USA (Venus closest approach 34,773 kilometers) Flag of the United States.svg USA (NASA) Mariner 2
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16 June 1963 First woman in space (Valentina Tereshkova) USSR Vostok 6
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3 February 1966 First soft landing on another world (the Moon)
First photos from another world USSR Luna 9 -
21 December 1968 First piloted orbital mission of another celestial body (Moon),first-ever Trans-Earth injection (25 December) USA (NASA) Apollo 8
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21 July 1969 First human on the Moon and first space launch from a celestial body USA (NASA) Apollo 11
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19 November 1969 First rendezvous on the surface of a celestial body USA (NASA) Apollo 12/Surveyor 3
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23 November 1970 First lunar rover USSR Lunokhod 1
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12 April 1981 First Reusable manned spacecraft (orbital) USA (NASA) STS-1
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24 January 1986 First Uranus flyby (closest approach 81,500 kilometers) USA (NASA) Voyager 2
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22 March 1995 Record longest duration spaceflight (437.7 days) set by Valeri Polyakov Russia Mir
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7 December 1995 First orbit of Jupiter USA (NASA) Galileo
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4 July 1997 First operational rover on another planet (Mars) Flag of the United States.svg USA (NASA) Mars Pathfinder
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12 February 2001 First landing on an asteroid (433 Eros) USA (NASA) NEAR Shoemaker
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14 January 2005 First soft landing on Titan ESA USA (NASA) ASI Cassini–Huygens
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15 January 2006 First sample return from comet (81P/Wild) USA (NASA) Stardust
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18 March 2011 First orbit of Mercury USA (NASA) MESSENGER
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25 August 2012 First manmade probe in interstellar space. USA (NASA) Voyager 1