Spread of the Black Death By avakoz 1320 Gobi Desert 1338 Lake Issyk Kul 1345 Lower Volga River 1346 Crimea and Caucasus 1347 Messina, Sicily 1347 Alexandria 1347 Constantinople 1347 Italy and Greece 1347 Egypt 1348 Britain and Ireland 1348 Genoa, Venice 1349 Northern Europe 1349 Mecca 1351 Yemen 1353 Moscow