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While studying medicine at the University of Edinburgh, he wrote his earliest extant fiction, a short story titled "The Haunted Grange of Goresthorpe".
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His first published piece "The Mystery of Sasassa Valley", a story set in South Africa, was printed in Chambers's Edinburgh Journal.
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He published his first non-fictional article, "Gelsemium as a Poison" in the British Medical Journal.
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In 1903, Conan Doyle published his first Holmes short story in ten years, "The Adventure of the Empty House"
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In 1885 Conan Doyle married Louisa (Louise) Hawkins, known as 'Touie', the sister of one of his patients. She suffered from tuberculosis and died on 4 July 1906.
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Marries Jean Elizabeth Leckie.
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Sir Arthur Conan Doyle was found clutching his chest in the hall of Windlesham, his house in Crowborough, East Sussex, on July 7, 1930. He died of a heart attack at the age of 71. His last words were directed toward his wife: "You are wonderful."
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Jean died in London on 27 June 1940.