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Fredrick Griffith
His major experiment studied 2 strains of Streptococcus Pneumonia. One with sugar coating and one with none. He tested different ways to mix the two strains together and put them in mice. Griffith concluded that there had been a transformation from live R bacteria to live S bacteria. This set the stage to search more for transforming substance -
Oswald Avery
Avery identified that Fred Griffith’s “transforming principle" was DNA. He concluded that the S bacteria were killed DNA was released. When some of the R bacteria would transfer DNA into their cells and changed them into S cells. But this was not accepted by others -
Rosalind Franklin and Maurice Wilkins
more InformationJoined 2 others to look at DNA structure also X-ray diffusion. -
Erwin Chargaff
analyzed the amount of adenine, guanine, thymine, cytosine in DNA of various species -
Hershey and Chase
The ProcessExperiment that proved phage DNA, and not protein, was the genetic material.
Conclusion: The active component of the bacteriophage that transmits the infective characteristic is the DNA. There is a clear correlation between DNA and genetic information. -
Watson and Crick
Worked at Cambridge University on DNA structure.
1. 2 outside strands consist of alternating deoxyribose and phosphate
2. cytocine and guanine bases pair to each other by 3 hydrogen bonds
3. thymine and adenine bases pair to each other by 2 hydrogen bonds
