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Born Alessandro Farnese in Canino.
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Ordained a priest at the age of 51.
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Elected Pope Paul III.
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Issued the bull Sublimus Dei, a landmark document that declared Indigenous peoples were human and not to be robbed of their freedom or possessions.
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Issued a second and final excommunication of Henry VIII of England.
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Pope Paul III's son, Pier Luigi, was assassinated at Piacenza.
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Pope Paul III died at the age of 81.