Outbreak By vmareshmead 10,000 BCE Malaria: Africa 1495 BCE Guinea Worm: Red Sea 430 BCE Unknown Disease: Athens 165 Smallpox: Rome 745 Smallpox: Japan 1000 Small Pox: China 1095 Ergotism: France 1200 Leprosy (Hansen's Disease): Europe 1249 Scurvy: Egypt 1331 Bubonic Plague: China 1348 Bubonic Plague: Europe 1485 Unknown Disease (The Sweating Sickness): England