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Isabella of Castile is born to John II of Castile and Isabella of Portugal in Madrigal de Las Altas Torres, Spain.
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Ferdinand II of Aragon is born to John II of Aragon and Juana Enriquez in Sos del Rey Catolico.
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Isabella of Castile and Ferdinand II of Aragon (second cousins) are married in Valladolid under a prenuptial agreement over share of power over land.
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Isabella of Castile gives birth to their first daughter, Isabel of Castile and Aragon.
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Isabella of Castile is annointed queen of Segovia after death of her brother Henry.
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Ferdinand II of Aragon is annointed kind of Segovia.
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Isabella of Castile gives birth to their one and only surviving son, John.
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Isabella of Castile gives birth to their second daughter, Joanna of Castile, also known as Joanna the Mad.
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Isabella of Castile gives birth to their third daughter, Maria of Aragon.
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Isabella of Castile gives birth to their fourth daughter, Catherine of Aragon.
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Isabella of Castile and Ferdinand II of Aragon defeat Granada, a Muslim Empire, and they are annexed by Castile, ending the Reconquista.
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Isabella of Castile and Ferdinand II of Aragon (Catholic Monarchs) ordered that all Jews be expelled from Spain and its territories by July 31 of that year. Ferdinand of II violated this treaty by forcing all Muslims in Castile or Aragon to convert to Catholicism or else be expelled. This was also used on the Jewish population of Spain.
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Isabella of Castile and Ferdinand II of Aragon sponser Columbus on his first voyage, which led to the discovery of San Salvador (now known as the Bahamas) and also led to the arrival of Europeans in the Americas.
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Isabella of Castile and Ferdinand II of Aragon sponsor Columbus on his second voyage to discover new territories, which led to the discovery of several islands.
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Isabella of Castile and Ferdinand II of Aragon sponsor Columbus on his third voyage to discover new territories, on which he discovers a series of islands.
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Ferdinand II of Aragon signed an agreement with Louis XII of France stating that Ferdinand would support French claims in Naples in exchange for getting territories for himself in the division of the kingdom.
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Ferdinand II of Aragon and Isabella of Castile sponsor Columbus on his fourth and final voyage in a search for the Straight of Maracca, only to find themselves stranded on Jamaica for a year.
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The first battle known to be won using gunpowder small arms, it was a battle between Spanish and French forces in in Cerignola, near Bari, Southern Italy. The Spanish forces, with 8,000 men, mroe than 1000 arequebusiers, 20 cannons defeated the French, which only had a force of 20,000 men, mainly cavalry and swiss mercenary pikemen, and about 40 cannons.
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The Spanish and French troops were separated by a river, and had by that point tried to cross it several times to no avail. The night of the 28, Spanish troops went to work building a bridge out of boats and barrels, and sneaking past the view of the French, made it across the Garigliano. By the next morning, over 6,000 had crossed and they attacked. When the 300 crossbowmen fled along with 300 French troops, the Spaniards took over the town.
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Ferdinand II of Aragon signed an agreement with Louis XII of France defining their controls over Italian territories. Spain would rule Sicily and southern Italy, and France would rule northern Italy from Milan.
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Isabella of Castile dies at the age of 53 years old (reason unknown)
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Ferdinand II of Castile marries his second wife, Germaine of Foix, after the death of Isabella of Castile. It is believed that he only married Germaine in hopes of having a male heir to separate Aragon from Castile and prevent his son-in-law Philip I and his grandson Charles I from inheriting power over Aragon.
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Germaine of Foix gives birth to her only child, John, but the child died only hours after birth.
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Ferdinand II of Aragon dies at the age of 63 years old (reasons unknown)