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Edward and Alphonse Elric attempt human transmutation to bring back their mother, Trisha Elric. Edward loses a leg, and alphonse loses is entire body. Ed sacrifices his arm to bind Al's soul to a suit of armor.
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Edward passes the State Alchemist exam at the age of 12 and is given the title "Fullmetal Alchemist"
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They leave Resembool to travel across Amestris in searech of the Philosopher's Stone to restore their bodies
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The war, which begins in 1901, ends with massive loss of live. Key characters like Roy Mustangs and Riza Hawkeye participate, shaping their motives
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The brothers encounter Father Cornello and the early signs of Homunculi interference
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The Elrics discover the honor of state Alchemy when Tucker sacrifices someone close to him to create a chimera
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Lt. Colonel Maes Hughes is murdered by Envy, deepening Mustang's resolve to expose the truth
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the brothers uncover experimentation with Philosopher's Stones and encounter Lust and Envy
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Through Hohenheim's memories and Scar's research, the origin of Father and the Homonculi is uncovered
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The brothers realize the entire country is a giant transmutation circle, designed to sacrifice the population for a new Philosopher's Stone
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They head to Briggs Fortress and meet Major General Olivier Armstrong. They learn more about the nationwide transmutation circle.
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Father initiates his plan during a solar eclipse to absorb the souls of Amestris and become a god-like being
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One by one, the homonculi are destroyed: Lust, Envy, Gluttony, Sloth, Pride, Greed, and Wrath.
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Edward defeats Father with the help of Hohenheim, Mustang, and the rest. Alphonse sacrifices himself to restore Ed's arm, and Ed returns the favor by giving up his alchemy to bring Al back to life.
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Ed and Al go their separate ways--Ed travels west to learn more about the world without alchemy, while Al heads east. Peace begins to return to Amestris.