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Despite being significantly before what is deemed as the Age of Exploration, it still marks the time when Europeans began to experience interest in westward travel.
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The Columbian Exchange marked the beginning of trade in resources among the New and Old World, leading to drastic changes among both of the regions. As a result, the New and Old World both experienced great changes in disease, resources, peoples, populations, etc.
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Well renowned as the most famous event in the era, it marked the true beginning of European interest in expanding their power across new lands. Additionally, it was the first time the Americas were recognized and known to the Europeans.
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This is one of the first examples of territorial claims to the New World by European powers, and split the newfound continents among Spain and Portugal in a straight line. Despite these claims not lasting very long, it demonstrated the European's driving desire to explore and conquer.
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John Cabot's landing in the New World marked England's first interaction with the Americas. In turn, this would lead to a long line of American influence and colonization of the New World in the next few centuries.
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This event is the first time that Greenland is re-explored since the voyages of Leif Erikson. Additionally, the Corte-Reals traveled to Greenland believing it was East Asia, showing that the late 15th century and early 16th century still had a large concept of thinking the New World was Asian.
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This titling of the New World as America, named after Amerigo Vespucci, gives a more colloquial name to the continents. This also goes to demonstrate that the lands are now under European influence due to them conjuring an "official" name for the lands.
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This is one of the first instances in which a power from Europe decides to impose its power on the Natives of the New World through violent means after the slaughters imposed by Christopher Columbus. This damage to the Aztec people greatly decreased the population of the Aztec tribe and solidified Spanish claims in modern-day Mexico.
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The execution of the last Incan emperor is another marking of European's power expanding in the New World. A shifting power dynamic becomes increasingly obvious as more tribe members and tribe leaders alike are killed by European explorers and militias.
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The discovery of the Mississippi River opened up a lot of new opportunities for travel and trade, making colonization of the Southeast United States a lot more convenient.
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