16th Century By Mya Casacuberta Apr 22, 1451 birth of Isabel I of Castile Mar 10, 1452 birth of Fernando ll of Aragón Jul 20, 1454 coronation of Enrique IV Oct 19, 1469 marriage of Isabel l of Spain and Fernando ll of Aragón Dec 11, 1474 death of Enrique IV Dec 13, 1474 coronation of Isabel I of Spain Jan 1, 1475 war of the Castilian succession Sep 4, 1478 the Holy Inquisition is established Sep 4, 1479 treaty of Alcáçovas Nov 6, 1479 birth of Juana I of Castile Jan 2, 1492 conquest of Granada Mar 31, 1492 expulsion of the Jews Oct 12, 1492 discovery of America Feb 24, 1500 birth of Charles I from Spain Oct 24, 1503 birth of Isabella of Portugal Nov 26, 1504 the coronation of Juana I of Castile Nov 26, 1504 death of Isabel of Castile l Jan 23, 1516 death of Fernando ll of Aragón Jan 25, 1516 Charles becomes King of Spain Oct 31, 1517 Martin Luther's 95 Theses spark Protestant Reformation Jun 28, 1519 Charles elected Holy Roman Emperor (as Charles V) Apr 16, 1520 comuneros Revolt in Castile; crushed by Charles May 25, 1521 diet of Worms: Charles condemns Luther Feb 24, 1525 battle of Pavia: Charles defeats Francis I of France Mar 19, 1526 marriatge of Charles I of Spain and Isabel of Portugal Mar 21, 1527 birth Philip II of Spain May 6, 1527 sack of Rome by Charles's troops Jun 1, 1535 Charles conquers Tunis from the Ottomans May 10, 1539 death of Isabella of Portugal Apr 12, 1555 death of Juana I of Castile Sep 25, 1555 Peace of Augsburg allows rulers in the Holy Roman Empire to choose Catholicism or Lutheranism 1556 Charles I of Sapin abdicates Aug 10, 1557 battle of St. Quentin: Spanish victory over France Sep 21, 1558 death of Charles I of Spain 1562 Philip II of Spain moves the capital to Madrid 1568 beginning of the Dutch Revolt against Spanish rule Oct 7, 1571 battle of Lepanto: naval victory over the Ottoman Empire 1580 Iberian Union: Philip becomes King of Portugal 1588 Spanish Armada defeated by England Sep 13, 1598 death of Philip II of Spain